PIWIL4 binds to cancer-associated protein coding RNA in AML cells and its depletion induces deregulation of LSC and DNA repair–associated pathways. (D) Heatmap of differentially expressed genes in shPIWIL4 vs scrambled transduced THP-1 cells, depicting expression of LSC-associated genes identified in HSC/CMP/GMP lineage LSCs from MLL-AF9, MOZ-TIF2, and MN1 models.