ADAMTS13 sequence variations reported in the 29 cases of pregnancy-onset cTTP. ADAMTS13 consists of several domains: a signal peptide (SP), a propeptide (PP), a metalloprotease domain (M), a disintegrin-like domain (D), a first thrombospondin type-1 repeat (T1), a cysteine-rich domain (C), a spacer domain (S), 7 additional thrombospondin type-1 repeats (T2-T8), and 2 CUB domains. Deleterious sequence variations of the ADAMTS13 gene appear in black whereas single-nucleotide polymorphism (SNPs) appear in gray.