Flowchart of the subgroup of patients with subsequent relapses and pregnancies as a function of pregnancy-onset TTP. A total of 12 relapses outside of pregnancies and 42 subsequent pregnancies were reported. Eleven relapses outside of pregnancies were observed in the 48 surviving patients with iTTP, 1 in the surviving 26 patients with uTTP, and none in the 29 surviving patients with cTTP. The 21 subsequent pregnancies reported in the iTTP group can be broken down into a no TTP–relapse group (18 pregnancies: 11 live births, 6 miscarriages, and 1 live birth complicated by PE) and a TTP-relapse group (3 pregnancies: 2 live births and 1 IUFD). All 3 of the subsequent pregnancies reported in the uTTP group ended in live births without relapses. Finally, 18 pregnancies were monitored in the cTTP group. One ended in an abortion and 14 were led with prophylactic plasmatherapy preventing a relapse in 13 pregnancies (12 live births and 1 miscarriage). Despite prophylactic plasmatherapy, 1 TTP relapse was reported, ending with a live birth. The final 3 were carried out without prophylactic plasmatherapy and were all marked by a TTP relapse, with 2 IUFD and 1 live birth.