EBNA2 is known to have multiple roles that promote lymphomagenesis and enable evasion of the host immune response. BCL2, B-cell lymphoma 2; BH3, Bcl2 homology domain 3; CIITA, class II major histocompatibility complex transactivator; HLA, human leukocyte antigen; ICOSL, inducible T-cell costimulator ligand; LMP1, latent membrane protein 1; PD-L1, programmed death ligand 1; TR, terminal repeat; vIL-10, viral interleukin 10.