MOP-C is predictive of outcomes in patients with CNSL. (A) Density plot depicting the distribution of MOP-C scores (0-1) within the training cohort. x-axis depicts MOP-C score; y-axis depicts density. Dashed lines indicate 2 density peaks (0.165; 0.5) used for the development of 3 separate risk groups: low risk ≤ 0.165; intermediate risk = 0.165-0.5; high risk ≥ 0.5. (B) Dot plot depicting MOP-C scores, comparing patients with and without relapse in the training and validation cohort. Each dot represents a single patient, dashed lines indicate the cut-offs between risk groups, color codes depict different risk groups, and numbers depict the percentage of patients with relapse within every risk group. (C) Comparison of FFS between patients with low-risk MOP-C scores (blue solid line), intermediate-risk MOP-C scores (red dashed line), and those with high-risk MOP-C scores (gray dashed line) in the training cohort (n = 48 patients). (D) Comparison of FFS between patients with low-risk MOP-C scores (blue solid line), patients with intermediate-risk MOP-C scores (red dashed line), and those with high-risk MOP-C scores (gray dashed line) in the validation cohort (n = 19 patients). (E) Comparison of FFS between patients with low-risk MOP-C scores (blue solid line), intermediate-risk MOP-C scores (red dashed line), and those with high-risk MOP-C scores (gray dashed line) in the whole study cohort (n = 67 patients). Statistical significance was assessed using log-rank tests (high risk vs low risk).