MOP-C improves current risk stratification strategies in CNSL. (A) Univariate analysis of the IELSG and MOP-C risk groups regarding FFS. HRs and 95% CIs are expressed per risk group (intermediate vs low risk, and high vs intermediate risk), respectively. Statistical significance was assessed using Cox regression analysis (n = 67 patients). (B) Sankey plot depicting patient flows from IELSG risk groups to MOP-C risk groups. Color code depicts different risk groups, and size of transition flows indicates number of patients. (C) Dot plot depicting MOP-C risk groups within the 3 IELSG risk groups, comparing patients with and without relapse. Each dot represents a single patient, dashed lines indicate the cut-offs between risk groups, color code depicts different MOP-C risk groups, and numbers depict the percentage of patients with relapse within every risk group.