HIV-Specific risk factors and odds of CHIP. Forest plot of multiple regression models for odds of CHIP, adjusting for age, natal sex, and smoking status. INSTI, integrase strand transfer inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitor; NRTI, nucleoside reverse transcriptase inhibitor; PI, protease inhibitor; TDF, tenofovir disoproxil fumarate.