Cumulative incidence of any progression (solid line) or progression at only a pre-ICI site (dashed line) among the complete cohort, regardless of number of sites of disease before ICIs (n = 69). Cumulative incidence of any progression at median follow-up of 4.0 years was 66.4%, and cumulative incidence of progression only at pre-ICI sites of disease was 39.4%. Death was a competing risk for both arms. Distant progression, or new sites of disease, was also a competing risk for cumulative incidence of progression at only pre-ICI site.