Cumulative incidence of any progression (solid line) or progression at only a pre-ICI site (dashed line) for the subset of patients (n = 45) with limited disease (≤5 sites pre-ICI). Cumulative incidence of any progression at median follow-up of 4.0 years was 58.9% among this cohort, and cumulative incidence of progression only at pre-ICI sites of disease was 34%. Death was a competing risk for both arms. Distant progression, or new sites of disease, were competing risks for patients in the progression at only pre-ICI site arm.