Gene mutations in the MLC BCP-ALL cases. (A) Recurrent driver mutations identified by variant calls from RNA sequencing and copy number variations from the single nucleotide polymorphism array, along with clinical information, for 111 BCP-ALL primary samples from the TARGET cohort. Cases are grouped as MLC or non-MLC according to miRNA expression clusters. (B) Gene mutations and MLC signature pairs showing co-occurrence or exclusivity in the 111 BCP-ALL primary samples from the TARGET cohort are illustrated as a triangular matrix. Green indicates a tendency toward co-occurrence, whereas brown indicates exclusivity. The point indicates P < .1, and the asterisk indicates P < .05. WBC, white blood cell.