Flow diagram describing the method for calculating the EWALL-PI for a patient.^§τ(MRD) was defined as the negative natural log of the absolute end of induction MRD level with undetectable MRD and MRD outside the quantitative range being assigned values of 1 × 10^–6 and 1 × 10^–5 respectively, whereas values ≥1 were rounded down to 0.99999. ^†For this study, τ(WCC) was defined as log(WCC + 1) rather than log(WCC) + 1 to avoid negative numbers resulting from WCC values below 0.4 × 10⁹/L. ^ŦGR-GEN and HR-GEN is coded as “1” if any of the listed genetic abnormalities is present, else “0.” ^∗The EWALL-PI is standardized to make it range from 0 to 10, as follows: EWALL-PI = ([actual EWALL-PI − EWALL-PI minimum]/[EWALL-PI maximum − EWALL-PI minimum]) × 10; where EWALL-PI minimum = −3.6381537 and EWALL-PI maximum = 2.0882617. The minimum and maximum value of EWALL-PI was derived based on existing data sets. High hyperdiploidy, 51 to 67 chromosomes; low hypodiploidy, 30 to 39 chromosomes, including masked low hypodiploidy with 60 to 78 chromosomes; near-haploidy, <30 chromosomes; complex karyotype, ≥5 chromosomal abnormalities detected by karyotype analysis excluding established ploidy subgroups; JAK-STAT, IGH::CRLF2, P2RY8::CRLF2, JAK2 fusions.