Frequency of circulating T cells and CD5 expression after CD5.CAR T-cell infusion. (A) The overall frequency of total CD3⁺ T cells in the peripheral blood of patients after CD5.CAR T-cell infusion. Statistical significance was evaluated by one-way analysis of variance. Levels of CD3⁺ CD4⁺ (B) and CD3⁺ CD8⁺ (C) T cells in the peripheral blood. (D) Expression of CD5 and CD5.CAR in CD3⁺ T cells from the peripheral blood (top) and lymph node biopsy samples at the indicated time points.