Individual changes in liver enzymes in patients with FA. The average of 3 values for ALT (U/mL) and AST (U/mL) graphed against the patient’s age in years using a fourth-order smoothing polynomial. Actual values of GGT (U/L) were plotted against the patient’s age in years (green). Shown are representative examples of changes in ALT (U/mL), AST (U/mL), and GGT (U/L) in (A) a patient who received HSCT at age 10.3 years; and (B) a patient who received HSCT at age 5.1 years. (C) A patient who never received HSCT and had liver enzyme elevations starting at birth. (D) A patient who had received androgen therapy and liver enzyme abnormalities were first observed at age 14.3 years.