Patterns of ALT variation in patients with FA with PLI. Changes in ALT in patients with FA with PLI are graphed and shown. Four patients are shown per graph for ease of comparison. The average of 3 values for ALT (U/mL) were used to graph these values against the patient’s age in years using a fourth-order smoothing polynomial. (A-E) ALT changes in each patient with FA who underwent HSCT and met criteria for PLI. The area under the curve is shaded for each patient and the time of stem cell infusion in recipients of HSCT are noted. (F) ALT changes in patients with PLI who did not receive HSCT.