Comparison between age at diagnosis in different groups of fibrinogen deficiencies and the association between factor activity levels and grades of severity. (A) The box plot compares the median age at diagnosis in 3 different fibrinogen deficiency groups. The solid line indicates the median. (B-C) The box plot compares the median factor activity levels between all grades of severity in quantitative (B) and qualitative (C) deficiencies. The Kruskal-Wallis test was performed to determine differences in the age at diagnosis between different subclasses of fibrinogen disorders. ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001.