Figure 7.
Clot dynamics after laser injury to cremaster muscle arterioles in puromycin-treated mice. (A) Representative images from hemostatic clots formed in vehicle- and puromycin-treated mice, 100 seconds after injury. Cd41, red; Cd62p, blue; fibrin, green. (B) Platelet accumulation, (C) Cd62p exposure, and (D) fibrin deposition were monitored by confocal intravital fluorescence microscopy; 32 injuries in 3 vehicle-treated mice, and 46 injuries in 3 puromycin-treated mice. Graphs in panels B-D shows the AUC for each. The lines and error bars indicate median and interquartile ranges. Vehicle, green lines and green closed circles; puromycin, red lines and red open circles.