Effects of age on plasma VWF:Ag levels in patients with low VWF compared with those in type 1 VWD subgroups. Plasma VWF:Ag levels were assessed in patients with low VWF and type 1 VWD at the time of first diagnosis and then subsequently repeated at time of enrollment into the national studies. The left dot depicts the mean plasma VWF:Ag and the corresponding mean age at time of original diagnosis and the right dot depicts mean plasma VWF:Ag and the corresponding mean age at trial enrollment. Broken lines with colored areas depict the standard deviations for separate groups. (A) Age-dependent increases in plasma VWF:Ag aligns for LoVIC participants and WiN patients whose plasma VWF levels increased ≥30 IU/dL. (B) Age-dependent increases in plasma VWF:Ag completely overlap for LoVIC patients compared with WiN patients whose plasma VWF levels normalized ≥50 IU/dL.