Genetic subtypes of patients with DLBCL. (A) Mantel-Haenszel χ2 of genetic subtypes related to IPI risk group. (B-C) Forest plots visualize hazard ratios (HRs) and P values obtained from the multivariate analysis of genetic subtypes and IPI for PFS and OS. (D) PFS into 4 main risk groups stratified by molecularly-enhanced IPI scores in training cohort. (E) PFS for IPI risk groups in training cohort. (F) Distribution of IPI risk factors across different genetic subtypes (∗P < .05 and ∗∗P < .01).