Schematics of hematopoietic developmental defect for patients with RAG2-SCID. (A) Overview of human T-cell (top) and (B) B-cell (bottom) developmental stages in the thymus and BM from cCLP. Dotted red squares mark developmental block for patients with RAG2-SCID. ∗DP, preselection double-positive stage; ∗∗DP, postselection double-positive stage; ETP, early thymic progenitor; ISP, immature single-positive stage.