Mutation landscape of the study cohort. (A) Comutation oncoprint of the study cohort. Genes with genomic alterations are listed in descending order of frequency. Each column represents a patient, and each row represents a gene alteration or clinical feature. The top barplot shows the number of mutations for each patient and the right barplot shows the percentage of samples that have alterations for each gene. The bottom heatmap shows the clinical parameters of each patient. (B) Correlation plot of the commonly mutated genes. Blue color indicates positive correlation and red color indicates negative correlation. Values represent the coefficients and significant pairs are shown. (C) Analysis of variant allele frequencies (VAFs) of MR defining mutations in the study cohort. The boxplot shows the median (solid line), 25^th, 75^th percentiles, and minimum and maximum VAF observed across the patients who harbored the MR gene mutations. The order is sorted by median VAF from high to low.