AML with 7q deletion that does not encompass NAMPT lacks sensitivity to NAMPT inhibition. (A) Genomic coverage plot showing the location of the deletion breakpoint in del(7q) AML samples with respect to the NAMPT gene locus. In 2 AML cases, a del(7q) breakpoint was on the telomeric side of NAMPT, maintaining the locus diploid (NAMPT^+/+). The deletion breakpoint locations were determined based on exome sequencing. (B) Ex vivo daporinad dose response of 2 NAMPT^+/+ AML samples with del(7q) compared with AML samples with NAMPT haploinsufficiency (NAMPT^+/−). Cell viability was measured by CTG (B), and cell death by CTxG (C).