Forest plots and regional association plots for 2 variants with time-dependent genetic effects for platelet count during pregnancy. Forest plots showing the genetic effect of rs12041331-G allele at 1q23.1 (PEAR1) (A) and rs12276986-T allele at 11q23.3 (CBL) (B) on meta-analysis for platelet count during the first, second, and third trimester, at delivery, and during the postpartum period. Points represent genetic effect (β). Hollow points indicate a P value not reaching genome-wide significance (P = 5 × 10^–8). The error bars indicate the 95% CI of β. Regional association plots from top to bottom represent the results of meta-analyses for platelet count during the first, second, and third trimesters at 1q23.1 (PEAR1) (C) and 11q23.3 (CBL) (D). The x-axis shows the chromosomal positions (GRCh38), and the y-axis indicates –log₁₀(P value) for the association tests. The purple diamond indicates the lead SNP of each locus. The other SNPs are colored based on their LD r² with the lead SNP. The dashed gray line represents the genome-wide significance threshold for GWAS (P = 5 × 10^–8). The gene track highlighted in red shows the nearest gene for the lead SNP.