CPX-351 prevents microbial dysbiosis. Metagenomic analysis in C57BL/6 mice treated IV with “7 + 3” combination or CPX-351 every 3 days for 3 times. Bar plots showing bacterial composition (abundance percentage) of each sample at (A) phylum and (B) genus levels. (C) Box plots of observed features and Shannon alpha diversity indexes. Box plots of (D) Jaccard and (E) Bray-Curtis beta diversity indexes at genus level, and scatterplot of the corresponding first 2 PCoA. (F) LEfSe cladogram and (G) LDA score histogram at the genus level. ∗P < .05; ∗∗P < .01; and ∗∗∗P < .001; treated vs untreated (None) mice and CPX-351 vs “7 + 3” treatment. Kruskal-Wallis test on all and pairwise samples. LDA, linear discriminant analysis.

CPX-351 prevents microbial dysbiosis. Metagenomic analysis in C57BL/6 mice treated IV with “7 + 3” combination or CPX-351 every 3 days for 3 times. Bar plots showing bacterial composition (abundance percentage) of each sample at (A) phylum and (B) genus levels. (C) Box plots of observed features and Shannon alpha diversity indexes. Box plots of (D) Jaccard and (E) Bray-Curtis beta diversity indexes at genus level, and scatterplot of the corresponding first 2 PCoA. (F) LEfSe cladogram and (G) LDA score histogram at the genus level. ∗P < .05; ∗∗P < .01; and ∗∗∗P < .001; treated vs untreated (None) mice and CPX-351 vs “7 + 3” treatment. Kruskal-Wallis test on all and pairwise samples. LDA, linear discriminant analysis.

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