AML stem cell dependency on PI3Kγ isoform through an AKT1-NRF2-PGD pathway. PGD supports nucleotide synthesis in the pentose phosphate pathway and suppresses ROS production to promote LSC maintenance. Professional illustration by Somersault18:24.
AML stem cell dependency on PI3Kγ isoform through an AKT1-NRF2-PGD pathway. PGD supports nucleotide synthesis in the pentose phosphate pathway and suppresses ROS production to promote LSC maintenance. Professional illustration by Somersault18:24.
