Overall survival based on receipt of CR1-allo. HRs represent the hazard of death associated with CR1-allo, from time-dependent Cox regression. (A) All NPM1 mutant AML, MRD positive (POS), in PB after 2 induction courses. Simon-Makuch plot of OS based on CR1-allo. (B) All NPM1 mutant AML, MRD negative (NEG), in PB after 2 induction courses. Simon-Makuch plot of OS based on CR1-allo. (C) Forest plot showing HR for death from CR1-allo (time-dependent Cox regression) within MRD subgroups, for all NPM1 mutant AML. (D) NPM1 mutant with FLT3-ITD AML, MRD POS, in PB after 2 induction courses. Simon-Makuch plot of OS based on CR1-allo. (E) NPM1 mutant with FLT3-ITD AML, MRD NEG, in PB after 2 induction courses. Simon-Makuch plot of OS based on CR1-allo. CR1 alloSCT, allogeneic stem cell transplantation in first complete remission.