The positive effects of macitentan on DVT outcomes are, at least in part, mediated by neutrophil integrin α9. (A) Schematic of experimental design. (B) Representative IVC thrombus harvested 48-hour post-stenosis from each group. (C) Thrombus weight (mg). Only mice that exhibited thrombosis were included to quantify the thrombus weight. Each dot represents a single mouse. (D) thrombosis incidence. Data are mean ± SEM and analyzed by repeated measures ANOVA followed by the corrected method of Benjamini and Yekutieli (C) or Fisher exact test (D); n = 20 (C-D).