Disease development is influenced by Rag1 expression but not TCR signaling. (A) Development of malignant disease was monitored in cohorts of TetIL-7R^ON mice, whose T cells have a polyclonal TCR repertoire (Poly; n = 8), and TCR transgenic F5 TetIL-7R^ON (F5; n = 6) and OTII TetIL-7R^ON (OTII; n = 10) mice. Survival of the different strains over time is shown. (B) Survival of cohorts of F5 TetIL-7R^ON (F5 Rag1⁺) and F5 Rag1^−/− TetIL-7R^ON (F5 Rag1⁻; n = 11) mice was monitored up to 400 days of age. ∗P = .018; n.s., nonsignificant; log-rank, Mantel-Cox test.