Comprehensive overview of TKI sensitivity based on the involved tyrosine kinase in ALL samples and transduced Ba/F3 models relative to BCR::ABL1-positive cells. For primary or primary xenografted ALL samples, the percentage of ALL samples by tyrosine kinase gene (ABL1, PDGFRB, CSF1R, or ABL2) with an area under the dose-response curve (AUC) above the median AUC of BCR::ABL1-positive ALL samples was calculated for each TKI (imatinib, dasatinib, or bosutinib). Colors were assigned based on the calculated percentages; green means ≤75% of the samples are above the median AUC of BCR::ABL1-positive ALL samples. Red indicates that >75% of the samples are above the median AUC of the BCR::ABL1-positive ALL samples. For CSF1R and ABL2, only 1 ALL sample was included in this study. This is denoted in the figure. For the transduced Ba/F3 models, green indicates that the half-maximal inhibitory concentration (IC₅₀) is below the IC₅₀ of the transduced Ba/F3 model expressing the BCR::ABL1 fusion, orange indicates an IC₅₀ above that of the BCR::ABL1 Ba/F3 model, and light green indicates a >10-fold lower IC₅₀ than that of the BCR::ABL1 Ba/F3 model.