Pooled change from baseline in LIC after treatment with mitapivat in patients with baseline iron overload. Patients were considered to have iron overload at baseline if they met at least 1 of 3 criteria: baseline ferritin of >1000 μg/L, baseline LIC of >3 mg Fe/g dw, and/or chelation therapy within the last year before start of treatment with mitapivat. The baseline for LIC by MRI is defined as the last assessment before randomization for patients randomized and not dosed, or the last assessment before the start of study treatment for patients randomized and dosed. BL, baseline.