Suppression of NF-κB repressor miR-146a exacerbates MPN pathogenesis. (A-I) Colony assay, leukemic engraftment in the PB, BM at end point, normalized spleen weights, survival curves, and BM histology in the 120770 pMF (A,C,E), 590888 pMF (B,D,F), and NBM2 (G-I) PDX models (n = 5 mice per group). PB human CD45⁺ (hCD45⁺) cells statistics assessed by 2-way ANOVA. Relative colony numbers (n = 3 biological replicates), BM hCD45⁺ and normalized spleen weights statistics assessed by 2-tailed Student t test. Survival curves assessed by log-rank test. Scale bar = 75 μm. x, no data.