Higher numbers and frequencies of NK cells and “memory-like” NK cells are associated with HCMV control in alloSCT recipients after discontinuation of letermovir. NK-cell reconstitution was compared in alloSCT recipients who controlled HCMV (controllers, blue) and those with csCMVi (brown). (A) Heat map comparing the MMRs (csCMVi/controllers) of selected NK-cell populations between the 2 cohorts. (B-E) Median absolute numbers (B) and frequencies (C) of CD56^dimCD159c⁺(CD57⁺) cells as well as numbers (D) and frequencies (E) of CD56^dimCD159c⁺⁺ (CD57⁺) cells are shown. (A-E) Mann-Whitney U test and Benjamini-Hochberg procedure to test for a FDR of <0.2. Significant results with an FDR >0.2 are indicated by the gray stars. (F-I) Individual numbers of (F) CD56^dimCD159c⁺, (G) CD56^dimCD159c⁺CD57⁺, (H) CD56^dimCD159c⁺⁺, (I) CD56^dimCD159c⁺⁺CD57⁺ on day +90 and day +210 are shown. (J,K) Individual absolute numbers of (J) CD56^dimCD159c⁺ and CD56^dimCD159c⁺CD57⁺ as well as (K) CD56^dimCD159c⁺⁺ and CD56^dimCD159c⁺⁺CD57⁺ before and after csCMVi are displayed. (F-K) ∗P < .05, ∗∗P < .01 using paired Wilcoxon test. CD, cluster of differentiation; d, day; MMR, median-to-median ratio.