Figure 4.
Severity of HCMV infection is linked to numbers and frequencies of HCMV–specific T cells. T-cell reconstitution was compared in alloSCT recipients who controlled HCMV (controllers, blue), those who experienced csCMVi without Rf/EOD (gray), and those who had csCMVi with Rf/EOD (red). (A) Absolute numbers of total Th cells (CD4+) and cytotoxic T cells (CD8+). (B-C) Background-corrected numbers and percentages of HCMV–specific Th cells (CD4+IFN-γ+, B) and cytotoxic T cells (CD8+IFN-γ+CD107a+, C) after 16 to 18 h of stimulation with pp65 HCMV-peptide mix. (A-C) Symbols/lines and error bars indicate medians and interquartile ranges, respectively. Kruskal-Wallis test and Benjamini-Hochberg procedure to test for a FDR of <0.2. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001. CD, cluster of differentiation.

Severity of HCMV infection is linked to numbers and frequencies of HCMV–specific T cells. T-cell reconstitution was compared in alloSCT recipients who controlled HCMV (controllers, blue), those who experienced csCMVi without Rf/EOD (gray), and those who had csCMVi with Rf/EOD (red). (A) Absolute numbers of total Th cells (CD4+) and cytotoxic T cells (CD8+). (B-C) Background-corrected numbers and percentages of HCMV–specific Th cells (CD4+IFN-γ+, B) and cytotoxic T cells (CD8+IFN-γ+CD107a+, C) after 16 to 18 h of stimulation with pp65 HCMV-peptide mix. (A-C) Symbols/lines and error bars indicate medians and interquartile ranges, respectively. Kruskal-Wallis test and Benjamini-Hochberg procedure to test for a FDR of <0.2. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001. CD, cluster of differentiation.

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