American Society of Hematology

Figure 1.

Spectrum of TNFRSF17 and GPRC5D mutations identified in post-TCE MM relapses. Somatic mutations identified in 2 studies13,14 are indicated on the protein structure. Extracellular, transmembrane, and cytoplasmic domains are annotated with a color code. TNFRSF17 mutations define hotspots in the extracellular domain and impact a single amino acid. By contrast, GPRC5D mutations are truncating and distributed all along the protein sequence.

Spectrum of TNFRSF17 and GPRC5D mutations identified in post-TCE MM relapses. Somatic mutations identified in 2 studies¹³^,¹⁴ are indicated on the protein structure. Extracellular, transmembrane, and cytoplasmic domains are annotated with a color code. TNFRSF17 mutations define hotspots in the extracellular domain and impact a single amino acid. By contrast, GPRC5D mutations are truncating and distributed all along the protein sequence.

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