Figure 3.
Two doses of CD70-CAR-IL-15 NK treatment eliminates Raji lymphoma cells in xenograft model. (A) Scheme of the in vivo evaluation of 2 doses of CD70-CAR-IL-15 NK infusion. (B) Kaplan-Meier plots showing the survival of tumor-bearing mice injected with the indicated CAR NK cells over 113 days. ∗∗P < .01. P values were determined by log-rank test. (C) Bioluminescent imaging without filters captures all luminescent signals in vivo (top), including Raji-CBG99#-BFP and Raji-CD19KO-CBRluc-GFP, and total flux analysis quantifies total tumor burden (bottom); n = 5 in the CAR NK group, and n = 3 in the NT-NK group. (D) Bioluminescent imaging with filter that selectively captures Raji-CBG99#-BFP luminescent signals in vivo (top) and the quantification of luminescence over time (bottom); n = 5 in the CAR NK group; and n = 3 in the NT-NK group. (E) Bioluminescent imaging with filter that selectively captures Raji-CD19KO-CBRluc-GFP luminescent signals in vivo (top) and the quantification of luminance over time (bottom); n = 5 in the CAR NK group; and n = 3 in the NT-NK group. ∗∗∗P < .001 and ∗∗∗∗P < .0001. P values were determined by 2-way ANOVA test, and Tukey test was engaged for post hoc analysis.

Two doses of CD70-CAR-IL-15 NK treatment eliminates Raji lymphoma cells in xenograft model. (A) Scheme of the in vivo evaluation of 2 doses of CD70-CAR-IL-15 NK infusion. (B) Kaplan-Meier plots showing the survival of tumor-bearing mice injected with the indicated CAR NK cells over 113 days. ∗∗P < .01. P values were determined by log-rank test. (C) Bioluminescent imaging without filters captures all luminescent signals in vivo (top), including Raji-CBG99#-BFP and Raji-CD19KO-CBRluc-GFP, and total flux analysis quantifies total tumor burden (bottom); n = 5 in the CAR NK group, and n = 3 in the NT-NK group. (D) Bioluminescent imaging with filter that selectively captures Raji-CBG99#-BFP luminescent signals in vivo (top) and the quantification of luminescence over time (bottom); n = 5 in the CAR NK group; and n = 3 in the NT-NK group. (E) Bioluminescent imaging with filter that selectively captures Raji-CD19KO-CBRluc-GFP luminescent signals in vivo (top) and the quantification of luminance over time (bottom); n = 5 in the CAR NK group; and n = 3 in the NT-NK group. ∗∗∗P < .001 and ∗∗∗∗P < .0001. P values were determined by 2-way ANOVA test, and Tukey test was engaged for post hoc analysis.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal