Concordance between WES and WGS predictions for the SCCRIP study. For the 396 patients with SCD enrolled in the SCCRIP study, machine learning increased the overall concordance rates between WES- and WGS-predicted RH genotypes from 90.3% for RHD and 96.3% for RHCE (A) to 97.2% for RHD, 98.2% for RHCE (B). The number and percentage of concordant alleles and various types of discordant alleles are shown in parentheses.