Kaplan–Meier curves of EFS and OS according to identified somatic mutations. (A-E) EFS according to ZBTB7A mutations (A), JAK2 mutations (B), CDKN2A mutations (C), TP53 mutations (D), and the combination of 4 mutations (E); and OS according to the combination of 4 mutations (F). P values for unadjusted Cox regression and for Cox regression adjusted for relevant prognostic factors (age at diagnosis, complex, trisomy 8, and monosomy 7) are reported.