Twelve-month NRM by risk classification for AREG and ST2 + REG3α biomarker algorithms (validation cohort). Pie charts show the proportion of patients classified as high-risk (HR, red border) and low-risk (LR, blue border). The proportions correctly classified as HR or LR are shaded in red and blue, respectively. The proportion incorrectly classified is shaded in gray. The cumulative incidence curves show the 12-month NRM, with shaded regions representing 95% confidence intervals. (A and B): All validation cohort patients (C and D): systemically treated subset. (A) ST2 + REG3α: NRM 39% vs 10%, P < .001; (B) AREG: NRM 29% vs 11%, P < .001; (C) ST2 + REG3α: NRM 39% vs 12%, P < .001; (D) AREG: NRM 31% vs 13%, P < .001.