Twelve-month NRM by Minnesota risk and further stratification using ST2 + REG3α and AREG algorithms in the validation cohort. The cumulative incidence curves show 12-month NRM with shaded regions representing the 95% confidence intervals. (A) Minnesota high-risk acute GVHD: NRM, 42%. (B) Minnesota high-risk stratified by ST2 + REG3α: NRM 45% vs 24%, P = .083; (C) Minnesota high-risk stratified by AREG: 50% vs 8%, P = .013. (D) Minnesota standard-risk acute GVHD: NRM, 15%. (E) Minnesota standard risk stratified ST2 + REG3α: NRM 34% vs 9%, P < .001; (F) Minnesota standard risk-stratified by AREG: NRM 21% vs 11%, P = .003.