Figure 4.
Effect of PAR1 biased agonism on biomarkers of coagulation and inflammation. SS bone marrow was transplanted into lethally irradiated WT (gray), R41Q (red), and R46Q (blue) mice. Four months later, mice were treated with SAL (steady state, solid bars) or TNF-α (2 mg/kg, IP) (white hashed bars), and plasma was collected after 5 hours (A). Plasma levels of TAT (B), IL-6 (C), HMGB1 (D), IL-18 (E), sVCAM-1 (F), sICAM (G), VWF (H), sP-sel (I), and PF4 (J). Data represent mean ± SEM for 6 to 8 mice (SAL, steady state) and 15 to 17 mice per group (TNF-α challenge). Asterisks above bar represent statistical significance vs SAL-treated mice of same genotype by 2-way ANOVA and Tukey post hoc test. Asterisks above brackets indicate comparison. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; and ∗∗∗∗P < .0001. SAL, saline.

Effect of PAR1 biased agonism on biomarkers of coagulation and inflammation. SS bone marrow was transplanted into lethally irradiated WT (gray), R41Q (red), and R46Q (blue) mice. Four months later, mice were treated with SAL (steady state, solid bars) or TNF-α (2 mg/kg, IP) (white hashed bars), and plasma was collected after 5 hours (A). Plasma levels of TAT (B), IL-6 (C), HMGB1 (D), IL-18 (E), sVCAM-1 (F), sICAM (G), VWF (H), sP-sel (I), and PF4 (J). Data represent mean ± SEM for 6 to 8 mice (SAL, steady state) and 15 to 17 mice per group (TNF-α challenge). Asterisks above bar represent statistical significance vs SAL-treated mice of same genotype by 2-way ANOVA and Tukey post hoc test. Asterisks above brackets indicate comparison. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; and ∗∗∗∗P < .0001. SAL, saline.

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