Total of 128 patients with TAM are classified into 3 groups by an unsupervised consensus clustering analysis based on cytokine profiling. (A) Based on unsupervised clustering, patients were classified into 3 cytokine groups (hot-1 [n = 37], hot-2 [n = 42], and cold groups [n = 49]). Missing data (1.1%) in 22 cytokines were imputed using the missForest method. Black boxes indicate each clinical feature. Gray boxes indicate patients with no data. (B-D) The mean cytokine differences (x-axis) and the negative log10-transformed statistical P value (y-axis) between hot-1 group and other groups (B), hot-2 group and other groups (C), cold group and other groups (D) are shown in the volcano plot.