Effect of PK and FXII deficiency on contact pathway–initiated TG. (A-C) Representative silica-initiated TG curves in Klkb1^+/+ and Klkb1^–/– mice PPP (A) with quantification of TG lag time (B) and peak TG (n = 5 per group) (C). (D-F) Representative silica-initiated TG curves in Klkb1^+/+ and Klkb1^–/– mouse WB (D) with quantification of TG lag time (E) and peak TG (n = 6-7 per group) (F). (G-I) Representative silica-initiated TG curves in F12^+/+ and F12^–/– mouse WB (G) with quantification of TG lag time (H) and peak TG (n = 5 per group) (I). Data are presented as individual values with median and interquartile range. Data are analyzed with Mann-Whitney U tests; ∗P < .05; ∗∗P < .01.