Effect of endogenous TF on contact pathway–initiated TG in WB. Representative curves of silica-initiated TG in TF^low or TF^wt mouse WB (A) and TF^low or TF^wt mouse WB (B) in the presence of 8 μM berotralstat and 50 μg/mL garadacimab with quantification of TG lag time (C) and peak TG (n = 4-5 per group) (D). Data presented as individual values with mean ± SD. Data analyzed with paired Student t tests comparing TF^low and TF^wt; ∗∗P < .01. Bero, berotralstat; ns, not significant; Veh, vehicle.