Association of the B-cell interactome with MM progression. (A) Diagram. Interactions were determined using CellPhoneDB²⁴ for patients with early or late relapse. (B) Comparison of the number of CellPhoneDB-predicted interactions between TTPlow and TTPhigh samples. (C) Diagram illustrating B-cell–centric interactions in which B cells interact with various other cell types. (D) Heat map comparing the interactome of B cells with other cell types in TTPlow vs TTPhigh patients. (E) Number of prognostic interactions vs total interactions by condition.