Changes in hematologic parameters over time. (A) Platelet levels for individual patients over time. n values for DFT baseline, Ext Scr, and years 1, 2, 3, 4, 5, and 6 are as follows: 6, 6, 6, 6, 6, 4, 1, and 2, respectively. There was no reported value at year 3 for P3; data from year 3.5 of treatment was used. (B) Lymphocyte levels for individual patients over time. n value for DFT baseline, Ext Scr, and years 1, 2, 3, 4, 5, and 6 are as follows: 6, 5, 6, 5, 6, 3, 1, and 1, respectively. P1 and P6 (dashed lines) were the only patients within range at the DFT. Asterisk denotes the latest time point for P6 that exceeded their individual lower limit of 0.5 × 109/L. (C) Neutrophil levels for individual patients over time. n values for DFT baseline, Ext Scr, and years 1, 2, 3, 4, and 5 are as follows: 6, 5, 6, 5, 6, 3, and 1, respectively. For lymphocytes and neutrophils, there was no reported value at year 3 or 1 for P3 and P1, respectively; data from year 3.5 and 0.5, respectively, were used. (D) Hemoglobin levels over time for individual female patients. n values for all time points are 2. There was no reported value at year 3 for P3; data from year 3.5 of treatment was used. (E) Hemoglobin levels over time for individual male patients. n values for DFT baseline, Ext Scr, and years 1, 2, 3, 4, and 5 are as follows: 4, 4, 4, 4, 4, 4, and 1, respectively. P1 and P6 (dashed lines) were the only patients within range at DFT baseline. Gray boxes indicate mean normal range that was determined by averaging lower and upper limit for all 6 patients (panels A-C), female patients only (panel D), or male patients only (panel E). Hgb, hemoglobin.
