FBL classification based on the molecular pathogenesis. The major driving event, the IG::MYC translocation, may occur in either EBV⁺ or EBV⁻ germinal center B-cell (GCBC, presumably an early centroblast). Thereafter, different additional genetic lesions (overall more abundant in EBV⁻ cases) would contribute to BL phenotype. In EBV⁻ cases, a major role seems to be played by SOX11 regulation, which is associated with specific gene expression as well as a mutational profile. Apparently, also the IG::MYC translocation itself is mediated by different mechanisms, namely somatic hypermutation (SHM) and class switch recombination (CSR), according to the EBV and SOX11 status.