Figure 3.
Mutational profile of BL primary cases according to EBV status and SOX11 expression. (A) Mutational analysis in recurrently mutated driver genes (mutated in ≥10% of cases) of 267 BLs. Mutations, EBV and SOX11 status, age group (pediatric or adult), and epidemiological variant (endemic or sporadic) are shown. The cases in the heat map are ordered by SOX11 and EBV status. (B) Frequencies of mutated cases in EBV+ (n = 110), EBV−/SOX11− (n = 76), and EBV−/SOX11+ (n = 81) for each gene are shown. Fisher exact test with false discovery rate correction was performed to evaluate differences in the frequencies between groups. ∗∗∗∗q value < 0.0001; ∗∗∗q value < 0.001; ∗∗q value < 0.01; ∗q value < 0.15.

Mutational profile of BL primary cases according to EBV status and SOX11 expression. (A) Mutational analysis in recurrently mutated driver genes (mutated in ≥10% of cases) of 267 BLs. Mutations, EBV and SOX11 status, age group (pediatric or adult), and epidemiological variant (endemic or sporadic) are shown. The cases in the heat map are ordered by SOX11 and EBV status. (B) Frequencies of mutated cases in EBV+ (n = 110), EBV−/SOX11− (n = 76), and EBV−/SOX11+ (n = 81) for each gene are shown. Fisher exact test with false discovery rate correction was performed to evaluate differences in the frequencies between groups. ∗∗∗∗q value < 0.0001; ∗∗∗q value < 0.001; ∗∗q value < 0.01; ∗q value < 0.15.

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