Genetic variants in LD with the LGR6 frameshift variant have been associated with viral infections. Genetic variants in LD with rs74355478 were found using the 1000 Genome Project cohort (phase 3) and their associations with phenotype were identified using phenotype association analysis (PheWAS) in the UK Biobank data set. LD plots indicating the r² value of the genetic variants (single dots) with rs74355478 in all populations (A) and European subpopulations (B). The colors of the dots indicate the population in which the SNPs in LD (black dotted line; r² > 0.8) with rs74355478 were identified. The location of the SNPs and LGR6 gene is based on the Grch37 human reference genome. (C) PheWAS analysis (logistic regression models considering as covariates sex, age, UK Biobank assessment center, and the 10 first principal components associated with population stratification) of rs4266947 in the British population (n = 431 367) of UK Biobank data set. The x-axis represents the different phenotypes grouped by domains, whereas the y-axis expresses the P value for each condition. Positive and negative associations are indicated with up- and down-pointing triangles, respectively. The blue dotted line indicates the statistical significance of P value <.05 and the red dotted line highlights statistical significance after multiple comparison corrections (Benjamini-Hochberg). NOS, not otherwise specified.