Primary and secondary MCL chromosomal alterations. (A) The left panel is a schematic representation of CCND1, CCND2, and CCND3 genes and their rearrangements with IGH, IGK, and IGL genes. The size of the arrows represents their frequency. The right panel indicates the molecular subtype according to the CCND gene rearrangement and cMCL or nnMCL. Note that still there are no reported MCL cases with CCND2 or CCND3 rearrangements of the nnMCL subset. (B) Circular representation of copy number alterations (CNA) and structural variants (SV) in MCL with whole-genome sequencing (WGS) and pretreatment (45 cMCL and 16 nnMCL).5 In the inner side, the primary SV, t(11;14) found in all cases, was represented by a thicker black line, whereas other alterations affecting (or very near) driver genes are represented by black lines (translocations) or gray lines (insertions); in the outer side, the CNA are colored (gains in blue and losses in red). Driver genes or regions frequently targeted by SV (in addition to gains and losses) are indicated. Note that no recurrent rearrangements were found.
