BCL6-R architecture. (A-C) Diagrams showing the architecture of MYC::IGH rearrangements at high resolution (top row) and the frequency of each rearrangement partner (bottom row) across DLBCL (A), HGBCL-DH-BCL2 (B), and HGBCL-DH-BCL6 (C). In each circular plot, the outermost ring gives the chromosome ideogram, followed by a genomic coordinate scale, a gene coordinate track, and a rainfall plot of intermutation distance with points colored according to whether the mutation overlaps the canonical AID WRCY motif (red) or not (black). Innermost lines show the linkages between BCL6 and IGH. (D) BCL6 expression measured from RNAseq data, stratified by lymphoma entity and BCL6-R partner. FDR-corrected Wilcoxon tests compared the expression of BCL6 stratified by rearrangement partner with that of DLBCL without BCL6-R. (E) Diagram showing MYC-R architecture in HGBCL-DH-BCL6. (F) MYC expression determined in HGBCL-DH-BCL6. FDR-corrected Wilcoxon tests compared the expression of MYC::IGH, all MYC::non-IGH, or false negative (tumors in which the MYC partner was not identified by sequencing) with the expression of MYC in DLBCL without MYC-R (“none”). ns, not significant; ∗P < .05; ∗∗∗∗P < .0001.