Combined administration of CD20-BsAbs with CD19-directed CAR T-cell treatment was investigated in primary samples from lymphoma types and in an immunocompetent murine CLL model. The addition of CD20-BsAbs supports CD19-directed CAR T cells by promoting CAR T-cell expansion and enhances the activity of endogenous T cells. NT, nontransduced T cells; PBS, phosphate-buffered saline. Professional illustration by Somersault18:24.